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Archive for the ‘Drugs’ Category

Generic Viagra And The Anniversary

18 Mar

Susan woke up with a smile on her face; it was her wedding anniversary, she and Dave had been married for five years now. She rolled over to give Dave a hug, when all she found was an empty bed. She wasn’t too happy that Dave had gone to work without saying goodbye. Thinking that maybe he wanted to let her enjoy sleeping late, she got up and began her day. Susan looked all over the house for some type of note from Dave; it wasn’t like him to forget this special day. She was rather surprised that she didn’t see one clue that he remembered it was their anniversary. She had no idea that Dave had Generic Viagra Mexico on his mind.

Heading off to work, she waited all day for flowers to arrive. Surely, Dave would have roses delivered to me, she thought. As she got her things to leave the office, she realized that no flowers were coming. Feeling very upset, she called him; no answer. Wondering why in the world his cell phone would go straight to his voice mail, she hung up her phone. She thought there was no sense in leaving a message, if he didn’t even remember the anniversary. She had no idea that Dave had Generic Viagra on his mind.

Driving home, she though that maybe he would have flowers waiting for her at the house. She ran inside to find whatever wonderful gift her husband would surprise her with. She looked in the living room, she looked in the kitchen, and she saw nothing. There were no flowers and no cards. Susan began to wonder how in the world he could forget that they were married for five wonderful years. Again, she had no idea that Dave had Generic Viagra on his mind. Then she noticed the answering machine had a message on it.

Susan stood in disbelief as she heard Dave’s voice telling her that he had to work late and would not be home for dinner. He told her that maybe she should just eat some leftovers, as he would be home very late. “Leftovers?” Susan yelled, as she grabbed some food from the night before. Susan was steaming mad, as she slammed the button to open the door to the microwave. She was about to find out that Dave had Generic Viagra and their anniversary on his mind.

And then she saw it: a note inside the microwave. It was written on crisp white paper and folder over so that it stood up. Opening it slowly, Susan read the words. “How could you think I would forget this special day, my love? Please go to our room, where you’ll find a beautiful dress I’ve purchased for you. At 7 o’clock, please open the front door. Love, Dave”

Susan smiled as she ran to her bedroom. There before her was a gorgeous red silk dress, and surrounding it in a circle were red flower petals. Getting ready, Susan made sure she looked beautiful for her wonderful husband. She sat on the sofa beginning at 6 o’clock, looking more stunning than ever.

At 7 o’clock, Susan opened the front door. A shiny, black limousine was parked in front of her house. Dave sat inside, clutching his Generic Cialis Canada as it was vital for the evening. He looked around to make sure the champagne was ready; slipped his Generic Viagra Pill into his pocket and then he opened the door to walk out and greet his wife. As the two of them headed off in the limo for a romantic dinner, Dave quickly swallowed his Generic Viagra and he felt rather proud of himself for bringing such an amazing smile to the most beautiful woman he had even seen.

 
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Viagra enhances treatment for brain metastasis

08 May

New research by scientists at Cedars-Sinai’s Maxine Dunitz Neurosurgical Institute suggests that a drug currently approved to treat erectile dysfunction may significantly enhance the delivery of the anti-cancer drug Herceptin to certain hard-to-treat brain tumors. The research, published in the journal PLoS ONE, could help doctors improve treatments for lung and breast cancers that have metastasized to the brain.

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While cancers that originate in the brain are relatively rare — approximately 22,000 patients are diagnosed with a primary brain tumor every year — nearly 10 times that many people develop brain tumors from cancers that began elsewhere in the body. Lung cancer remains the leading cause of cancer death in the U.S., and about 20 percent of lung cancers metastasize to the brain. Breast cancer and melanoma may also spread to the brain, and once this happens, the cancer becomes extremely difficult to treat and the prognosis turns poor.

Even if a cancer is susceptible to drugs, these drugs must penetrate the “blood-brain barrier” if they’re to treat cancer that’s metastasized to the brain. “Mother Nature created this barrier to protect our brains from dangerous substances, but here we need to get through the barrier to deliver the drugs, and that’s a problem,” says study author Julia Y. Ljubimova, M.D., Ph.D., a research scientist at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute in Los Angeles.

Keith Black, M.D., chairman of Cedars-Sinai’s Department of Neurosurgery and director of the Maxine Dunitz Neurosurgical Institute, is the lead research scientist on this project and senior author of the paper. He has studied the blood-brain barrier for about two decades, and his work in this field received the Jacob Javits award from the National Advisory Neurological Disorders and Stroke Council of the National Institutes of Health in June 2000. Since then, research conducted by his team found that the erectile dysfunction drugs sildenafil (Viagra) and vardenafil (Levitra), which inhibit the enzyme phosphodiesterase 5 (PDE5), could increase the permeability of the blood-brain tumor barrier and boost the effectiveness of the chemotherapy drug doxorubicin.

“No matter how effective against cancer a chemotherapeutic agent may be, it can have little impact on brain tumors if it cannot cross the blood-brain tumor barrier,” he said. “As we find new drugs that are able to target these tumor cells, it is imperative that we develop better ways to enable the medications to reach their targets.”

In the current study, the researchers examined whether PDE5 inhibitors might also increase the blood-brain tumor barrier’s permeability to Herceptin, a monoclonal antibody used to treat lung and breast tumors that are positive for HER2/neu. Herceptin is a large molecule that does not easily cross the blood-brain tumor barrier, a limitation that severely reduces its effectiveness at treating brain metastases.

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The researchers first measured vardenafil’s effects on the permeability of the blood-brain tumor barrier. Using a mouse model, the scientists showed that vardenafil led to a two-fold increase in the amount of Herceptin that reached brain metastases of lung and breast cancers. Next, they examined whether this increase in blood-brain barrier permeability improved Herceptin’s effectiveness at treating these brain metastases by giving mice vardenafil in tandem with Herceptin. The results showed that the combination of vardenafil plus Herceptin boosted mean survival by 20 percent, compared to Herceptin alone (72+/-18 days versus 59+/-9 days).

Mice whose tumors were not HER2-positive did not experience the same increase in survival that those with HER2-positive tumors did when given vardenafil, indicating that the survival benefit was indeed due to an increase in the amount of Herceptin reaching the tumors, says Ljubimova.

“Now that we’ve demonstrated that big molecules can cross the blood-brain tumor barrier, we’re going to continue this strategy with other big molecule drugs, such as nanomedicine drugs” says Ljubimova. “This opens a new world for brain tumor treatments.”

Source: http://www.sciencedaily.com/releases/2010/05/100507175257.htm

 
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Viagra, Cialis, Lefitra for Erectile Dysfunction Treatment

29 Mar

How Viagra, Levitra, and Cialis Work

Levitra (generic name: vardenafil; brand names include: Vivanza / Yaila) is a prescription medicine that is used to treat erectile dysfunction (ED) and can help you get and keep a quality erection, so that you can make the most of each sexual experience. Levitra online Mexico
Cialis (generic name: tadalafil; brand names include: Tadacip / Scifil / Apcalis / Forzest) is an FDA-approved prescription medicine used to treat erectile dysfunction, more commonly known as impotence. A man is impotent if he cannot achieve or sustain an erect penis for sexual activity.
Mexican pharmacy Viagra (sildenafil citrate; brand names include: Aphrodil / Edegra / Erasmo / Penegra / Revatio / Supra / Silagra / Zwagra) is an effective treatment for erectile dysfunction regardless of the cause or duration of the problem or the age of the patient.

 
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Mexican generic viagra facts

15 Mar

Here are some facts that you should note down before you buy generic Viagra (Sildenafil).

Generic Viagra is a phosphodiesterase-5 inhibitor that works by way of blocking he agents found in the patient’s blood that otherwise would block the free blood flow in penile tissues, preventing the taker from achieving and maintaining sufficient erection required for a sexual intercourse. Please mind that the drug should be taken at least 30 minutes before the supposed sexual activity, and strict compliance with the rules of intake should be observed. Scan accurately through the list of generic Viagra contraindications as well as pharmacological and physiological incompatibilities before you start taking the drug.

The drug remains to be efficient in the patient’s organism for the ensuing 4 to 5 hours depending on personal peculiarities of the organism that can vary immensely from one patient to another. The patients who take generic Viagra point out that their sexual life becomes more enjoyable thanks to increased sensitivity of penile tissues and faster recharges coupled with better control over the length of the sexual act.

Caution should be taken with the dosage of the drug. Under no circumstances a double dose of the medicine should be taken; this will not result neither in a more prolonged or intensify effect, nor in a shortened reuptake period, but can only provoke development of adverse side effects, some of which can be very dangerous and cause permanent damages. Provided that you are following all of the recommendations given in the manufacturer’s manual absolute safety is guaranteed.

Keep in mind that no erection will be achieved unless a suitable sexual is provided. Do not take generic Viagra together with drinks containing alcohol or large amount of caffeine. If you experience palpitations, dizziness, difficult breathing, impaired vision or certain other conditions you should immediately discontinue the use of the drug until your physician gives you permission to recommence taking generic Viagra.

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However, certain patients need to have the regular dose of Sildenafil contained in one tablet of Viagra adjusted for them, therefore you should not skip the appointments with your doctor for monitoring your current health conditions and the possible changes caused by Sildenafil therapy.

Apply for your doctor’s help immediately if you experience abnormally prolonged erection that lasts more than 4 hours.

Generic Viagra, much the same as its brand equivalent, needs to be stored in a cool dry place away from the sources of hit and out of the reach of children and pets.

 
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