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Prediction of the Need for ICU Treatment in Univariate and Multivariate Regression Analysis

09 Oct

Age, sex, comorbidities, outpatient medication, oxygen saturation on hospital admission, and the duration of the current episode of AECOPD of the patients requiring ICU treatment did not differ significantly from the overall patient cohort. In univariate Cox regression analysis BNP, accurately predicted the need for ICU care (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.03 to 1.22 for an increase in BNP of 100 pg/mL; p = 0.009). This strong association persisted in multivariate analysis (HR, 1.13; 95% CI, 1.03 to 124 for an increase in BNP of 100 pg/mL; p = 0.008) [Table 2]. To the contrary, BNP levels did not differ significantly between survivors and in-hospital nonsurvivors (64 pg/mL [IQR, 32 to 195 pg/mL] vs 81 pg/mL [IQR, 57 to 1,103]; p = 0.362).

BNP Levels as Prognostic Marker for Medium- and Long-term Mortality

Overall, 16 patients (7%) died during the 6-month follow-up period and 46 patients (22%) died within 2 years of the initial hospitalization. AECOPD (16 patients), cardiac death (7 patients), and pneumonia (6 patients) were the most common causes of death. BNP levels on presentation did not differ significantly between nonsurvivors and survivors after 6 months of follow-up (67.3 pg/mL [IQR, 49.5 to 184.9] vs 63.5.7 pg/mL [IQR, 31.7 to 194.5];p = 0.610).

Table 2—Prediction of the Need for ICU Treatment with Viagra Australia in Univariate and Multivariate Regression Analysis

HR p
Predictors (95% CI) Value

Univariate analysis

Age 0.988 (0.937-1.042) 0.651
Anthonisen class 1.643 (0.978-2.761) 0.061
BNP, for an increase 1.118(1.029-1.215) 0.009
of 100 pg/mL
CRP 1.005 (0.995-1.015) 0.334
GOLD class 0.826 (0.496-1.376) 0.436
Left ventricular 0.974 (0.947-1.002) 0.068
ejection fraction Cheap viagra online
Paco2 on hospital 1.038(1.001-1.077) 0.042
admission
Procalcitonin 1.080 (0.734-1.588) 0.696
Pulmonary arterial 1.011 (0.964-1.061) 0.646
pressure
Serum pH mexican online pharmacy 0.001 (0.000-0.438) 0.026
Multivariate analysis
BNP, for an increase 1.133 (1.033-1.242) 0.008
of 100 pg/mL
Paco2 on hospital 1.069 (1.007-1.134) 0.029
admission
Serum pH 16.449 (0.01-217918) 0.563
 
 

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